Andrade debuted for his hometown club C.F. Estrela da Amadora in 1997, during their most successful season ever as they finished 7th in the first division. Andrade immediately caught the eye, and in 2000 was on the move north, to F.C. Porto. He was Porto’s most-used player in the 2001-02 Champions League, playing 12 times as the team reached the second group phase.
On April 21 2004, during a UEFA Champions League semi-finals match against former team Porto, Andrade was sent off by referee Markus Merk for a kick on Deco. The gesture was of a friendly nature, but Merk was eluded by it, and immediately sent Andrade off.
Andrade was subsequently courted by numerous clubs, including Chelsea, Liverpool, Manchester United, Barcelona, Valencia and Inter Milan, but ended up signing for Juventus FC in summer 2007. In a match against AS Roma, he badly broke his left rotula and missed the rest of the 2007–08 season.
In the team's 2008 preseason, Andrade again snapped the same kneecap and missed the entire 2008-09. In a press release dated 7/8/08, Juventus stated:
"On 9 July 2008, during a training session at Pinzolo, the player Almeida Gomes de Andrade, Jorge Manuel, was the victim of another serious injury to his left knee (relapse of the fracture of the rotula) operated twice in the past season. A new osteosynthesis operation was thus needed. The post-surgery prognosis is a number of months.That was the third in a year and the fourth left knee surgery Andrade had in his career.
Given the impossibility for the player to recover to play professionally, the company has proceeded to fully write down the residual book value of the player's registration rights with a negative effect on the 2007-08 financial year for € 6.8 million.
Andrade, along with fellow Portuguese internationals Miguel, Nani and Nélson, is a descendant from the tiny Cape Verde islands. He visited his homeland in 2006 and did some work with grassroots football during his stay.