Orotic acid

Orotic acid

Orotic acid is a heterocyclic compound and an acid; it is also known as pyrimidinecarboxylic acid. Historically it was believed to be part of the Vitamin B complex and was called vitamin B13, but it is now known that it is not a vitamin, instead manufactured in the body by intestinal flora.

Its salts, known as orotates, are sometimes used as mineral carriers in some dietary supplements, to increase their bioavailability. Lithium orotate is the most frequently used in this manner.


A buildup can lead to orotic aciduria.

In ornithine transcarbamoylase deficiency, a disorder of the urea cycle, excess carbamoyl phospate is converted into orotic acid. This typically leads to increased urinary orotic acid excretion.

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