nucleotidyltransferase

Gentamicin 2"-nucleotidyltransferase

In enzymology, a gentamicin 2"-nucleotidyltransferase is an enzyme that catalyzes the chemical reaction

nucleoside triphosphate + gentamicin rightleftharpoons diphosphate + 2"-nucleotidylgentamicin

Thus, the two substrates of this enzyme are nucleoside triphosphate and gentamicin, whereas its two products are diphosphate and 2-nucleotidylgentamicin.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is NTP:gentamicin 2"-nucleotidyltransferase. Other names in common use include gentamicin 2"-adenylyltransferase, aminoglycoside adenylyltransferase, and gentamicin 2"-nucleotidyltransferase.

References

  • Angelatou F, Litsas SB, Kontomichalou P "Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa". J. Antibiot. 235–44.
  • Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H "The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B". J. Antibiot. 913–4.
  • Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T "Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor". J. Antibiot. 911–2.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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