The actions of some drugs mimic those of naturally occurring neurotransmitters. The pain-regulating endorphins, for example, are similar in structure to heroin and codeine, which fill endorphin receptors to accomplish their effects. The wakefulness that follows caffeine consumption is the result of its blocking the effects of adenosine, a neurotransmitter that inhibits brain activity. Abnormalities in the production or functioning of certain neurotransmitters have been implicated in a number of diseases including Parkinson's disease, amyotrophic lateral sclerosis, and clinical depression.
Chemical released by neurons to stimulate neighbouring neurons, allowing impulses to be passed from one cell to the next throughout the nervous system. A nerve impulse arriving at the axon terminal of one neuron stimulates release of a neurotransmitter, which crosses the microscopic gap (see synapse) in milliseconds to the adjoining neuron's dendrite. Many chemicals are believed to act as neurotransmitters. The few that have been identified include acetylcholine, dopamine, and serotonin. Some neurotransmitters activate neurons; others inhibit them. Some mind-altering drugs act by changing synaptic activity.
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