Naphazoline (in the hydrochloride form) is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. It is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion. It is an active ingredient in Naphcon-A and Clearine eye drops.
It has the molecular formula C14H14N2.HCl and a molecular weight of 246.73 g/mol.
A few warnings and contraindications that apply to all naphazoline-containing substances intended for medicinal use are:
A possible association with stroke has been suggested.