This is a list of notable, historically testified people who mysteriously disappeared, and whose current whereabouts are unknown or whose deaths are not substantiated.
- Owain Glyndŵr, the last native Welsh person to hold the title Prince of Wales, instigated the Welsh Revolt against the rule of Henry IV of England in 1400. Although initially successful, the uprising was eventually put down, but Glyndŵr disappeared and was never captured, betrayed, or tempted by Royal Pardons. Nothing certain is now known of him after 1412, but efforts to identify his grave continue.
- John Cabot: Italian explorer. His vessel disappeared, along with four other ships, during a voyage to find a western route from Europe to Asia.
1587 or 1588
- Theodosia Burr Alston, daughter of U.S. Vice President Aaron Burr and sometimes called the most educated American woman of her day, left on December 30, 1812, aboard the Patriot and sailed out of the harbor in Georgetown, South Carolina. The ship was never seen again.
- Khachatur Abovian (b.1809), Armenian writer and national public figure of the early 19th century, credited as creator of modern Armenian literature, left his house early one morning and was never heard from again.
- Joshua Slocum: an American seaman and adventurer (the first man to sail single-handedly around the world) disappeared in November 1909 while aboard his sloop-rigged fishing boat that he had named Spray.
- Bobby Dunbar, age 4, disappeared during a fishing trip in St. Landry Parish, Louisiana. A child found in the custody of William Cantwell Walters of Mississippi some eight months later was ruled to be Bobby Dunbar by a court-appointed arbiter, and Walters was found guilty of kidnapping, but the conviction was overturned on appeal. The child grew up as Bobby Dunbar, had four children of his own, and died in 1966. In 2004, DNA tests proved that the child found was not related to Bobby Dunbar's brother, Alonzo.
- Arthur Cravan, French proto-dadaist writer and art critic, disappeared near Salina Cruz, Mexico, in November 1918, most likely drowning during a sailing trip in the Pacific Ocean.
- The captain and crew of the Carroll A. Deering, found beached near Cape Hatteras, North Carolina.
- Percy Fawcett (58), British archaeologist and explorer, together with his eldest son Jack and friend Raleigh Rimmell, were last seen travelling into the jungle of Mato Grosso in Brazil to search for a hidden "city of gold". Several unconfirmed sightings and many conflicting reports and theories explaining their disappearance followed, but despite the loss of over 100 lives in more than a dozen follow-up expeditions, and the recovery of some of Fawcett's belongings, their fate remains a mystery.
- Frederick McDonald (53), Australian politician, set off from Martin Place, Sydney to a meeting two blocks away with Jack Lang but failed to arrive and was never heard from again. He was possibly murdered by his political rival Thomas John Ley. In 1947, Ley was convicted at the Old Bailey of "the chalkpit murder" of a barman in England and sentenced to hang, but then declared insane and sent to Broadmoor high security psychiatric hospital where he died of a cerebral hemorrhage two months later.
- Joseph Force Crater, Associate Justice of the New York Supreme Court, was last seen entering a New York City taxi cab, and his mistress Sally Lou Ritz went missing a few weeks later;neither was ever heard from again. Crater's disappearance prompted one of the most sensational manhunts of the 20th century, was the subject of widespread media attention and a grand jury investigation, and the term "pull a Crater" became common slang for a person vanishing. He was declared legally dead in 1939 and his missing persons file was officially closed in 1979, but Cold Case Squad detectives have investigated new leads as recently as 2005.
- Joseph Rodriguez: Four-year-old child and resident of Spanish Harlem, New York City, who disappeared in 1936 while playing with friends. Although Rodriguez' aunt received a telegram informing her that her nephew had been injured and would return home shortly, Joseph never appeared. There was no further communication from the writer and no trace of Joseph's body was ever found.
- Curtis Chillingworth was a judge in the U.S. state of Florida who (together with his wife, Marjorie Chillingworth) disappeared from his Manapalan, Florida, home in June 1955. Authorities later learned that the couple were abducted, taken offshore and killed as part of a murder-for-hire plot.
- The crew and passengers of the Joyita, which disappeared in the South Pacific ocean; five weeks later, the Joyita re-appeared with no one on board.
- Weldon Kees, U.S. poet. On July 19, 1955, Kees's Plymouth Savoy was found on the north side of the Golden Gate Bridge with the keys in the ignition. He left no note and his body was never found, but he was known to have talked about packing up and moving to Mexico.
- Camilo Cienfuegos was a Cuban revolutionary. He disappeared and presumably died on October 28, 1959, in a Cessna accident due to bad weather while flying over the sea. However, neither his plane nor his body was ever recovered despite Cuban government efforts.
- Donald Crowhurst - English businessman and amateur sailor who died while competing in a single-handed, round-the-world yacht race.
- Oscar Zeta Acosta: American attorney and Chicano activist. Most famous for portrayal as "Dr. Gonzo" in Hunter S. Thompson's book, Fear and Loathing in Las Vegas.
- Richard Bingham, 7th Earl of Lucan, whose whereabouts have been unknown since his children's nanny, Sandra Rivett, was beaten to death with a lead pipe in the basement of his estranged wife's home. In 1975, Lord Lucan was the last person ever to be deemed a murderer by a coroner's jury. He was officially declared dead in 1999.
- Malcolm ("Mac") Graham: An avid U.S. yachting enthusiast from San Diego, California, disappeared along with his wife from Palmyra Atoll sometime between August 28 and August 30, 1974. Although he is believed to have been murdered, and his wife's remains were found in 1981, his own remains have never been located.
- Renee MacRae and her 3 year old son Andrew were last seen in Inverness, Scotland. They are thought to have been murdered and their remains have never been found. Their disappearance is Britain's longest running missing person's case. Northern Constabulary renewed their search for evidence in 2004 and named a suspect in a report to the procurator fiscal in October 2006, however the Crown Office declared there was insufficient evidence to go to court.
- Suzy Lamplugh, a British estate agent who went missing from Fulham, West London and was declared dead, presumed murdered, in 1994. Despite further police investigations in 1998 and 2000, no trace of her has ever been found.
- The Springfield Three - Sherrill Levitt (47), her daughter Suzie Streeter (19), and Suzie's friend Stacy McCall (18) - disappeared from Levitt's home in Springfield, Missouri, in an apparent triple kidnapping and murder.
- Maura Murray: an American college student from Massachusetts, who disappeared after a one-car accident in New Hampshire.
- irena asher: a 25 years old new zealand woman last seen the 10th of october 2004,around 1am near piha beach,40km from auckland
- Natalee Holloway, an American teenager, was last seen leaving a nightclub in Aruba with three men.
- Ray Gricar: District Attorney in the U.S. state of Pennsylvania
- Charles Rutherford Jr.: Attorney who disappeared with his girlfriend in Lake Huron; her body was later found.
- Patrick McDermott: partner of Olivia Newton-John; disappeared on return from a fishing cruise off San Pedro, California.
- George Allen Smith: from Greenwich, Connecticut, United States, was discovered to be missing on July 5, 2005, ten days after his wedding to Jennifer Hagel Smith, while cruising the eastern Mediterranean Sea between Greece and Turkey aboard the Royal Caribbean cruise ship, Brilliance of the Seas.
- Joe Pichler, an American child actor, vanished from his home town of Bremerton, Washington at the age of 18. Four days after he was last heard from, his car was found above the Port Madison Narrows; inside, police discovered a note which they characterized as a suicide note. The message expressed suicidal thoughts and asked that his belongings go to his younger brother, but did not explicitly state that he intended to take his own life.
- Jorge Julio López, Argentine retired bricklayer, was kidnapped during the National Reorganization Process, and disappeared again during the democratic government of President Néstor Kirchner after testifying in trial against Dirty War criminal Miguel Etchecolatz.
- Sivasubramaniam Raveendranath, a Sri Lankan Tamil academic and Vice Chancellor of the Eastern University of Sri Lanka, disappeared while attending a conference in Colombo.
- Jim Gray (63), database pioneer, Microsoft research scientist, and Turing Award winner, left San Francisco Bay in his 12 meter sailboat to scatter his mother's ashes at the Farallon Islands, a wildlife refuge 43 km away, and was reported missing when he failed to return later the same day. No Mayday call was heard, his distress radiobeacon was not activated, and despite one of the most ambitious search and rescue missions of all time, no trace of Gray or his yacht was ever found.
- Derek Batten (56), and brothers Peter Tunstead (69) and James Tunstead (63), departed Shute Harbour for Townsville, Queensland aboard Batten's 9.8 meter catamaran Kaz II. Five days later when the yacht was found adrift with its sails up and engine running, all three crew were missing and the Global Positioning System showed it had been drifting since around the time of their last known radio contact, about 11 hours after leaving Shute Harbour.
- Steve Fossett (63), American aviator, sailor, and adventurer went missing on September 3 and was declared legally dead the following February. The wreckage of the light aircraft he had been flying solo at the time of his disappearance was found near Mammoth Lakes, California in October 2008. Some of his personal belongings were also discovered nearby, but Fossett himself is still missing.
- Madeleine McCann, a 3-year-old British girl, went missing after being left unsupervised in the unlocked ground floor bedroom of her family's rented holiday apartment in the Algarve (Portugal). There have been no confirmed sightings of her since she disappeared.
- Leonid Rozhetskin (41), Russian-born British media magnate, disappeared from his house in Jūrmala, Latvia, in what Latvian police described as "extremely worrying circumstances", and may have been the victim of a political murder plot.
- Caylee Anthony, disappeared in June. Much speculation has been pointed at her mother, Casey Anthony.