monounsaturated fatty acid

Long-chain-fatty-acid-(acyl-carrier-protein) ligase

In enzymology, a long-chain-fatty-acid-[acyl-carrier-protein] ligase is an enzyme that catalyzes the chemical reaction

ATP + an acid + [acyl-carrier-protein] rightleftharpoons AMP + diphosphate + acyl-[acyl-carrier-protein]

The 3 substrates of this enzyme are ATP, acid, and [acyl-carrier-protein], whereas its 3 products are AMP, diphosphate, and acyl-[acyl-carrier-protein].

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is long-chain-fatty-acid:[acyl-carrier-protein] ligase (AMP-forming). Other names in common use include acyl-[acyl-carrier-protein] synthetase, acyl-[acyl carrier protein] synthetase, acyl-ACP synthetase, acyl-[acyl-carrier-protein]synthetase, stearoyl-ACP synthetase, and acyl-acyl carrier protein synthetase. This enzyme participates in fatty acid metabolism.


  • Ray TK, Cronan JE Jr "Activation of long chain fatty acids with acyl carrier protein: demonstration of a new enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli". Proc. Natl. Acad. Sci. U. S. A. 73 4374–8.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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