|Branch of NS||Position||Neurotransmitter|
|*Except fibers to sweat glands and certain blood vessels|
According to their targets, motoneurons are classified into three broad categories:
General visceral motoneurons — "visceral motoneurons" for short — which indirectly innervate smooth muscles of the viscera (like the heart, and the muscles of the arteries): they synapse onto neurons located in ganglia of the autonomic nervous system (sympathetic and parasympathetic), located in the peripheral nervous system (PNS), which themselves directly innervate visceral muscles (and also some gland cells).
In other words:
It could be argued that, in the command of visceral muscles, the ganglionic neuron — parasympathetic or sympathetic — is the real “motoneuron”, being the one that directly innervates the muscle (whereas the “general visceral motoneuron” is, strictly speaking, a “preganglionic” neuron). But, for historical reasons, the term motoneuron is reserved for the CNS neuron.
All motoneurons are cholinergic, that is, they release the neurotransmitter acetylcholine. Parasympathetic ganglionic neurons are also cholinergic, whereas most sympathetic ganglionic neurons are noradrenergic, that is, they release the neurotransmitter noradrenaline. (see Table)
The interface between a motoneuron and muscle fiber is a specialized synapse called the neuromuscular junction. Upon adequate stimulation, the motoneuron releases a flood of neurotransmitters that bind to postsynaptic receptors and triggers a response in the muscle fiber.
In addition to voluntary skeletal muscle contraction, alpha motoneurons also contribute to muscle tone, the continuous force generated by noncontracting muscle to oppose stretching. When a muscle is stretched, sensory neurons within the muscle spindle detect the degree of stretch and send a signal to the CNS. The CNS activates alpha motoneurons in the spinal cord, which cause extrafusal muscle fibers to contract and thereby resist further stretching. This process is also called the stretch reflex.
Gamma motoneurons regulate the sensitivity of the spindle to muscle stretching. With activation of gamma neurons, intrafusal muscle fibers contract so that only a small stretch is required to activate spindle sensory neurons and the stretch reflex.