Miller's masterpiece, Death of a Salesman (1949; Pulitzer Prize), is the story of a salesman betrayed by his own hollow values and those of American society. The Crucible (1953) is both a dynamic dramatization of the 17th-century Salem witch trials and a parable about the United States in the McCarthy era (see McCarthy, Joseph Raymond); it has been his most frequently produced work. In A View from the Bridge (1955; Pulitzer Prize) Miller studies a Sicilian-American longshoreman whose unacknowledged lust for his niece destroys him and his family. Miller's tumultuous life with his second wife, Marilyn Monroe, to whom he was married from 1956 to 1961, is fictionalized in his After the Fall (1964), and a barely disguised version of the glamorous but troubled actress also appears in his last play, Finishing the Picture (2004).
Miller's other plays include The Man Who Had All the Luck (1940), All My Sons (1947), Incident at Vichy (1965), The Price (1968), The Creation of the World and Other Business (1972), The American Clock (1980), The Ride down Mount Morgan (1991), Broken Glass (1994), and Resurrection Blues (2002). He also wrote the screenplay for The Misfits (1961); the television dramas Playing for Time (1980) and Clara (1991); a novel, Focus (1945); and two books of short stories (1967, 2007). Miller's The Theater Essays (1971, rev. ed. 1996) is a collection of writings about the craft of playwriting and the nature of modern tragedy, and Echoes down the Corridor (2000) is a collection of essays (1944-2000), many of them autobiographical. He collaborated with his third wife, the photographer Inge Morath (1923-2002), on several books; their In Russia (1969) is a study of the Soviet Union.
See his autobiography, Timebends (1987); M. C. Roudane, Conversations with Arthur Miller (1987), S. Centola, Arthur Miller in Conversation (1993), M. Gussow, Conversations with Miller (2002); biographies by M. Gottfried (2003) and C. Bigsby (2008); studies by B. Nelson (1970), R. Hayman (1972), J. J. Martine, ed. (1979), D. Welland (1979, repr. 1985), L. Moss (rev. ed. 1980), H. Bloom, ed. (1987), J. Schlueter and J. K. Flanagan (1987), N. Carson (1988), P. Singh (1990), S. R. Centola, ed. (1995), A. Griffin (1996), T. Otten (2002), C. Bigsby (2004), and E. Brater, ed. (2005).
See G. T. Simon, Glen Miller and His Orchestra (1974, repr. 1980); J. Green, Glenn Miller and the Age of Swing (1976); P. Tanner and B. Cox, "Every Night Was New Year's Eve": On the Road with Glenn Miller (1992); discography by C. Garrod (1995).
See his autobiography My Life and Times (1972); memoir by K. Winslow (1986). See biographies by J. Miller (1978) and R. Ferguson (1991); W. A. Gordon, The Mind and Art of Henry Miller (1967), E. B. Mitchell, ed., Henry Miller (1971), and N. Mailer, Black Messiah (1981).
See his A Whole Different Ball Game (1991, repr. 2004).
The Miller-Urey experiment (or Urey-Miller experiment) was an experiment that simulated hypothetical conditions present on the early Earth and tested for the occurrence of chemical evolution. Specifically, the experiment tested Oparin and Haldane's hypothesis that conditions on the primitive Earth favored chemical reactions that synthesized organic compounds from inorganic precursors. Considered to be the classic experiment on the origin of life, it was conducted in 1953 by Stanley L. Miller and Harold C. Urey at the University of Chicago.
At the end of one week of continuous operation Miller and Urey observed that as much as 10-15% of the carbon within the system was now in the form of organic compounds. Two percent of the carbon had formed amino acids that are used to make proteins in living cells, with glycine as the most abundant. Sugars, lipids, and some of the building blocks for nucleic acids were also formed.
In an interview, Stanley Miller stated: "Just turning on the spark in a basic pre-biotic experiment will yield 11 out of 20 amino acids."
There also had been similar electric discharge experiments related to the origin of life contemporaneous with Miller-Urey. An article in The New York Times (March 8, 1953:E9), titled "Looking Back Two Billion Years" describes the work of Wollman (William) M. MacNevin at Ohio State University, before the Miller Science paper was published in May 1953. MacNevin was passing 100,000 volt sparks through methane and water vapor and produced "resinous solids" that were "too complex for analysis." The article describes other early earth experiments being done by MacNevin. It is not clear if he ever published any of these results in the primary scientific literature.
K. A. Wilde submitted a paper to Science on December 15, 1952, before Miller submitted his paper to the same journal on February 14, 1953. Wilde's paper was published on July 10, 1953. Wilde only used voltages up to 600 V on a binary mixture of carbon dioxide and water in a flow system. He only observed small amounts of carbon dioxide reduction to carbon monoxide and no other significant reduction products or newly formed carbon compounds.
More recent experiments by chemist Jeffrey Bada at Scripps Institution of Oceanography, La Jolla, Calif. were similar to those performed by Miller. However, Bada noted that in current models of early Earth conditions carbon dioxide and nitrogen create nitrites, which destroy amino acids as fast as they form. However, the early Earth may have had significant amounts of iron and carbonate minerals able to neutralize the effects of the nitrites. When Bada performed the Miller-type experiment with the addition of iron and carbonate minerals, the products were rich in amino acids. This suggests the origin of significant amounts of amino acids may have occurred on Earth even with an atmosphere containing carbon dioxide and nitrogen.
In 2006 another experiment showed that a thick organic haze might have blanketed Early Earth. An organic haze can form over a wide range of methane and carbon dioxide concentrations, believed to be present in the atmosphere of Early Earth. After forming, these organic molecules would have floated down all over the Earth, allowing life to flourish globally.
Originally it was thought that the primitive secondary atmosphere contained mostly NH3 and CH4. However, it is likely that most of the atmospheric carbon was CO2 with perhaps some CO and the nitrogen mostly N2. In practice gas mixtures containing CO, CO2, N2, etc. give much the same products as those containing CH4 and NH3 so long as there is no O2. The H atoms come mostly from water vapor. In fact, in order to generate aromatic amino acids under primitive earth conditions it is necessary to use less hydrogen-rich gaseous mixtures. Most of the natural amino acids, hydroxyacids, purines, pyrimidines, and sugars have been produced in variants of the Miller experiment.
More recent results may question these conclusions. The University of Waterloo and University of Colorado conducted simulations in 2005 that indicated that the early atmosphere of Earth could have contained up to 40 percent hydrogen — implying a much more hospitable environment for the formation of prebiotic organic molecules. The escape of hydrogen from Earth's atmosphere into space may have occurred at only one percent of the rate previously believed based on revised estimates of the upper atmosphere's temperature. One of the authors, Owen Toon notes: "In this new scenario, organics can be produced efficiently in the early atmosphere, leading us back to the organic-rich soup-in-the-ocean concept... I think this study makes the experiments by Miller and others relevant again." Outgassing calculations using a chondritic model for the early earth complement the Waterloo/Colorado results in re-establishing the importance of the Miller-Urey experiment.
Although lightning storms are thought to have been very common in the primordial atmosphere, they are not thought to have been as common as the amount of electricity used by the Miller-Urey experiment implied. These factors suggest that much lower concentrations of biochemicals would have been produced on Earth than was originally predicted (although the time scale would be 100 million years instead of a week). Similar experiments, both with different sources of energy and with different mixtures of gases, have resulted in amino and hydroxy acids being produced; it is likely that at least some organic compounds would have been generated on the early Earth.
However, when oxygen gas is added to this mixture, no organic molecules are formed. Opponents of Miller-Urey hypothesis seized upon recent research that shows the presence of uranium in sediments dated to 3.7 Ga and indicates it was transported in solution by oxygenated water (otherwise it would have precipitated out). These opponents argue that this presence of oxygen precludes the formation of prebiotic molecules via a Miller-Urey-like scenario, attempting to invalidate the hypothesis of abiogenesis. However, the authors of the paper are arguing that this presence of oxygen merely evidences the existence of photosynthetic organisms 3.7 Ga ago (a date about 200 Ma earlier than previous estimates) a conclusion which while pushing back the time frame in which Miller-Urey reactions and abiogenesis could potentially have occurred, would not preclude them. Though there is somewhat controversial evidence for very small (less than 0.1%) amounts of oxygen in the atmosphere almost as old as Earth's oldest rocks, the authors are not in any way arguing for the existence of an oxygen-rich atmosphere any earlier than previously thought, and they state: ". . . In fact most evidence suggests that oxygenic photosynthesis was present during time periods from which there is evidence for a non-oxygenic atmosphere".
Conditions similar to those of the Miller-Urey experiments are present in other regions of the solar system, often substituting ultraviolet light for lightning as the driving force for chemical reactions. The Murchison meteorite that fell near Murchison, Victoria, Australia in 1969 was found to contain over 90 different amino acids, nineteen of which are found in Earth life. Comets and other icy outer-solar-system bodies are thought to contain large amounts of complex carbon compounds (such as tholins) formed by these processes, in some cases so much so that the surfaces of these bodies are turned dark red or as black as asphalt. The early Earth was bombarded heavily by comets, possibly providing a large supply of complex organic molecules along with the water and other volatiles they contributed. This has been used to infer an origin of life outside of Earth: the Panspermia hypothesis.