Guié-Mien began his career at top-division AS Inter Brazzaville in the Congolese capital. At the age of 19, during the 1997-98 season, he moved to Germany to play for Karlsruher SC in the Bundesliga. By around halfway into the season he had made himself a regular starter through his playing skills as an attacking midfielder and forward. However he could not prevent the team being relegated into the 2. Bundesliga.
In the 1998-99 season he confirmed his initial promise and was ever-present as a key member of the team. However they narrowly missed out on promotion back into the Bundesliga.
Guié-Mien was then approached by Bundesliga side Eintracht Frankfurt and agreed to join them before the start of 1999-2000. Here too he quickly became central to the team's plans, but again, after survival in his first year, the club dropped into the second division the following season.
Frankfurt failed to come straight back up in 2001-02, and after a very successful start to the following season, with his best goal tally before the winter break to date, Guié-Mien moved to promotion-challengers SC Freiburg. In the event both teams were promoted that season. His spell at Freiburg, lasting until the end of 2003-04, was disappointing. He made just 25 appearances, many as a substitute lasting only a few minutes.
His next move was to 1. FC Köln, just relegated from the Bundesliga. There he was again unable to play himself into the starting eleven, achieving only the status of a squad player, and sometimes found himself playing for the amateur side in the Regionalliga. Since moving to Freiburg his continuing skilful play has stood in stark contrast to his inability to score goals. Up to the end of 2004-05 he failed to score in 50 consecutive league matches.
His contract at Köln ran until the end of the 2005-06 season. However, after the appointment of Hanspeter Latour as manager, the club decided to release him early, and put him up for free transfer immediately after the 2005-06 winter break training. In September 2006 Guié-Mien signed for Oberliga side FC Sachsen Leipzig, where he played for one season. Since summer 2007 he has been contracted to Rot-Weiss Essen in the Regionalliga.
Guié-Mien is a current player for his national side.