, small erythematous
or haemorrhagic macular
lesions on the palms
only a few millimeters in diameter that are pathognomonic
of infective endocarditis
. Pathologically, the lesion is described to be a microabscess
of the dermis
with marked necrosis
and inflammatory infiltrate not involving the epidermis
, which is due to the deposition of circulating immune complexes
in small blood vessels.
They are named after Edward G. Janeway (1841–1911), a professor of medicine with interests in cardiology and infectious disease.