refers to the complete set of small-molecule metabolites (such as metabolic intermediates, hormones and other signalling molecules, and secondary metabolites) to be found within a biological sample, such as a single organism. The word was coined in analogy with transcriptomics
; like the transcriptome and the proteome, the metabolome is dynamic, changing from second to second. Although the metabolome can be defined readily enough, it is not currently possible to analyse the entire range of metabolites by a single analytical method (see metabolomics
). In January 2007 scientists at the University of Alberta and the University of Calgary finished a draft of the human metabolome. They have catalogued and characterized 2,500 metabolites
, 1,200 drugs
and 3,500 food components that can be found in the human body.
- First use of the term "metabolome" in the literature —Oliver SG, Winson MK, Kell DB, Baganz F (1998). "Systematic functional analysis of the yeast genome". Trends Biotechnol. 16 (9): 373–8.
- First book on metabolomics —Harrigan, G. G. & Goodacre, R. (eds) (2003). RMetabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis. Kluwer Academic Publishers (Boston). ISBN xxx-xxx.
- Fiehn O, Kloska S, Altmann T (2001). "Integrated studies on plant biology using multiparallel techniques". Curr. Opin. Biotechnol. 12 (1): 82–6.
- Fiehn O (2001). "Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks". Comp. Funct. Genomics 2 (3): 155–68.
- Weckwerth W (2003). "Metabolomics in systems biology". Annu Rev Plant Biol 54 669–89.
- Goodacre R, Vaidyanathan S, Dunn WB, Harrigan GG, Kell DB (2004). "Metabolomics by numbers: acquiring and understanding global metabolite data". Trends Biotechnol. 22 (5): 245–52.
- Wishart DS, Tzur D, Knox C, Eisner R, Guo AC, Young N, Cheng D, Jewell K, Arndt D, Sawhney S, Fung C, Nikolai L, Lewis M, Coutouly M-A, Forsythe I, Tang P, Shrivastava S, Jeroncic K, Stothard P, Amegbey G, Block D, Hau DD, Wagner J, Miniaci J, Clements M, Gebremedhin M, Guo N, Zhang Y, Duggan GE, MacInnis GD, Weljie AM, Dowlatabadi R, Bamforth F, Clive D, Greiner R, Li L, Marrie T, Sykes BD, Vogel HJ, Querengesser L "HMDB: The Human Metabolome Database". Nucleic Acids Research 35 (Database issue) D521-6.
- Nicholson JK, Holmes E, Lindon JC, Wilson ID (2004). "The challenges of modeling mammalian biocomplexity". Nat. Biotechnol. 22 (10): 1268–74. . Stresses the role of intestinal microorganisms in contributing to the human metabolome.
- van der Greef J, Stroobant P, van der Heijden R (2004). "The role of analytical sciences in medical systems biology". Curr Opin Chem Biol 8 (5): 559–65.
Kell DB (2004). "Metabolomics and systems biology: making sense of the soup". Curr. Opin. Microbiol. 7 (3): 296–307.
Dunn, W.B. and Ellis, D.I. (2005) Metabolomics: current analytical platforms and methodologies. Trends in Analytical Chemistry 24(4), 285-294.
Ellis DI, Goodacre R (2006). "Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy". Analyst 131 (8): 875–85.
- The importance of analytical sciences to omics and systems biology.
- Metabolomic data as an input to systems biology models.