(marketed as Mesantoin
by Novartis) is a hydantoin
, used as an anticonvulsant
. It was introduced approximately 10 years after phenytoin
, in the late 1940s. The significant metabolite
of mephenytoin is nirvanol
(5-ethyl-5-phenylhydantoin), which was the first hydantoin (briefly used as a hypnotic
). However, nirvanol is quite toxic and mephenytoin was only considered after other less toxic anticonvulsants had failed. It can cause potentially fatal blood dyscrasia
in 1% of patients.
Mephenytoin is no longer available in the US or the UK. It is still studied largely because of its interesting hydroxylation polymorphism.
- The Treatment of Epilepsy edited by S. D. Shorvon, David R. Fish, Emilio Perucca, W. Edwin Dodson. Blackwell Publishing. 2004. ISBN 0-632-06046-8
- The Medical Treatment of Epilepsy by Stanley R Resor. Published by Marcel Dekker (1991). ISBN 0-8247-8549-5.
- The Comparative Toxicogenomics Database: Mephenytoin