meninges, three membranous layers of connective tissue that envelop the brain and spinal cord (see nervous system). The outermost layer, or dura mater, is extremely tough and is fused with the membranous lining of the skull. In the brain it forms a vertical sheet that separates the cerebral hemispheres and a horizontal sheet that lies between the cerebrum and the cerebellum. The thin arachnoid membrane lies below and in close contact with the dura mater. The innermost layer, or pia mater, is in direct contact with the brain and spinal cord and contains the blood vessels that supply them. The pia mater and arachnoid membrane are separated by the subarachnoid space containing the cerebrospinal fluid, which carries nutrients, absorbs the impact of shocks, and acts as a barrier to disease organisms. Thus, the meninges provide a fluid-filled jacket for the protection of neural tissues and allow for the flexing and twisting of the vertebral column about the spinal cord.

Three fibrous membranes that surround the brain and spinal cord to protect the central nervous system. The pia mater, a very thin membrane, adheres to the surface of the brain and spinal cord. The subarachnoid space, containing cerebrospinal fluid, separates the pia mater from a second membrane, the arachnoid. Around the brain, fine filaments connect these two membranes, which are believed to be impermeable to fluid. The third membrane, the dura mater, is strong, thick, and dense. It envelops the arachnoid, covers the inside of the skull, and surrounds and supports the large venous channels carrying blood from the brain. Several septa divide it and support different parts of the brain. In the spine, the dura mater and the arachnoid mater are separated by the subdural space; the arachnoid and pia mater are separated by the subarachnoid space. The extradural space (between the dura mater and the wall of the vertebral canal) is the site of epidural anesthesia (see anesthesiology).

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