2-coumarate reductase

In enzymology, a 2-coumarate reductase is an enzyme that catalyzes the chemical reaction

3-(2-hydroxyphenyl)propanoate + NAD+ rightleftharpoons 2-coumarate + NADH + H+

Thus, the two substrates of this enzyme are 3-(2-hydroxyphenyl)propanoate and NAD+, whereas its 3 products are 2-coumarate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase. This enzyme is also called melilotate dehydrogenase. This enzyme participates in phenylalanine metabolism.


  • Levy CC and Weinstein GD "The metabolism of coumarin by a microorganism. II. The reduction of o-coumaric acid to melilotic acid". Biochemistry 3 1944–1947.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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