Mastermind or Masterminds may refer to:

In books:

• The Master Mind of Mars, a science fiction novel by Edgar Rice Burroughs

In clothing:

• Mastermind Japan, a line of specialty menswear

In comics:

• Mastermind (Jason Wyngarde), a Marvel Comics supervillain, an adversary of the X-Men
• Mastermind (Martinique Jason) or Lady Mastermind, his two daughters
• Mastermind (computer), the alien artificial intelligence that first appeared in Captain Britain
• Master Mind (comic strip), a strip in the British comic Buster
• Mastermind Excello, a name used by two unrelated Marvel Comics superheroes

In film:

• The Master Mind, a 1914 American black & white silent movie
• Masterminds (film), a 1997 film starring Patrick Stewart
• Master Mind (2010 film), an upcoming computer animated film from Dreamworks Animation, scheduled for release in 2010.

In games:

• Mastermind (board game), a code-breaking board game for two players
• Mastermind, a character archetype in the computer game City of Villains

In music:

• Mastermind (U.S. band), a progressive rock band from New Jersey
• Mastermind (Japanese band), a power metal band from Japan
• Dr. Mastermind, a rock band featuring current Journey drummer Deen Castronovo
• Mastermind (album), the 2005 album by British dance diva Tina Cousins
• Mastermind, a 2005 album by hip-hop artist Qsic
• Herbie the Mastermind, a British DJ
• "Mastermind" a track from Mike Oldfield's The Millennium Bell album
• Mastermind, a 2008 single from Mindless Self Indulgence.
• "Mastermind" a track from Megadeth's Cryptic Writings album

In psychology:

• Mastermind (Role Variant), one of the 16 role variants that the Keirsey Temperament Sorter is based on
• INTJ (Mastermind), a Myers-Briggs Type Indicator

In television:

• Mastermind (TV series), a British quiz show
• International Mastermind, Mastermind India, Junior Mastermind, spin-offs of the show
• Masterminds (Canadian TV series), a Canadian TV series airing on History Television in Canada, and Court TV in the US.
• Masterminds (Quiz Bowl), the television show on Time Warner TW3, broadcasting the Quiz Bowl games from the Albany, New York area.