Dr. Cline was the first to successfully transfer a functioning gene into a living mouse, creating the first transgenic organism. His research has also pertained to the molecular genetic alterations in cancer, especially in leukemia.
In 1980, Dr. Martin Cline conducted a rDNA transfer into the bone marrow cells of two patients with hereditary blood disorders. He did so in direct opposition to National Institute of Health gene therapy guidelines and without the approval of the Institutional Review Board at the University of California Los Angeles (UCLA), where his research was conducted. The ethical concerns that were generated prompted a call for review by a number of organizations – including the National Council of Churches, Synagogue Council of America, and the United States Catholic Conference. Consequently, Dr. Cline was forced to resign his department chairmanship at UCLA and lost several research grants. http://www.family.org/cforum/fosi/bioethics/genetics/a0032608.cfm