It has published an array of fiction and non-fiction by authors such as Mark Ames, Cristin O'Keefe Aptowicz, Paul Berman, Lisa Crystal Carver, Dennis Cooper, Brian Gage, Douglas A. Martin, William Upski Wimsatt, James Hatfield, Maggie Estep, Nick Mamatas, Lydia Millet, Daniel Nester, Wanda Phipps, Genesis P-Orridge, Nate Powell, Jack Sargeant, K. Thor Jensen, Lynne Tillman, Ken Dolan-Del Vecchio and Tim Wise.
In December 2005, Richard Eoin Nash, on behalf of Soft Skull Press, was the recipient of the Miriam Bass Award for Creativity in Independent Publishing.
The press currently is located on West 21st Street in New York City, NY.
In 2007, Michael McColly's The After-Death Room won the 2007 Lambda Literary Award for Spirituality. The same year, the Matthew Sharpe's Jameston was nominated for a 2007 Quill Award for Fiction (but lost for Cormac McCarthy's The Road), Chris Mazza's Oh Pure and Radiant Heart was shortlisted for the Arthur C Clarke Award for Science Fiction writing and Alain Mabancko's African Psycho was on The Believe Book Awards 2007 Shortlist.
In 2004, Soft Skull Press won the 2004 Lambda Literary Award for Transgender/GenderQueer with Charlie Anders' book Choir Boy. Several other Soft Skull book were nomated for 2004 Lambda Literary Awards, including That's Revolting!: Queer Strategies for Resisting Assimilation ("Anthologies/Nonfiction"), The Haunted Hillbilly ("Gay Men's Fiction"), Skels ("Lesbian Fiction"), Juicy Mother ("Humor"), Manstealing for Fat Girls ("Debut Lesbian Fiction") and Deliver Me from Nowhere ("Transgender/GenderQueer"), among others.