O-Acetylpsilocin

O-Acetylpsilocin, 4-acetoxy-N,N-dimethyltryptamine, or 4-AcO-DMT is a psychedelic (hallucinogenic). It is the acetylated form of the psychedelic mushroom alkaloid psilocin, and is a lower homologue of 4-AcO-DET and 4-AcO-DiPT. It may also be considered an analogue of psilocin and DMT, which are Schedule I drugs under the Controlled Substances Act of the USA.

History

O-Acetylpsilocin is a newer psychedelic with a limited history.

Chemistry

O-Acetylpsilocin can be obtained by acetylation of psilocin under strongly acidic or under alkaline conditions. It is a synthetic compound. O-Acetylpsilocin is more resistant than psilocin to oxidation under basic conditions due to its acetoxy group.

Pharmacology

See psilocybin for more details.

In the body 4-acetylpsilocin is evidently rapidly desacetylated to psilocin by acetylases and therefore has identical pharmacological properties to psilocin.

Dosage

A dose of O-acetylpsilocin is 8 mg - 30 mg. These are slightly lower than that of the free phenol, psilocin. Some report very strong effects with 15 mg. The duration of 4-acetylpsilocin is usually slightly longer than that of psilocin at about 4-7 hours.

See also

• Psilocybin
• Tryptamine
• Indole
• Psychedelic drug
• Psychoactive drug
• Manna
• Teonanactl
• Ayahuasca
• Soma

External links

• Improvements to the Synthesis of Psilocybin and a Facile Method for Preparing the O-Acetyl Prodrug of Psilocin - A publication by David E. Nichols
• The Big And Dandy 4-AcO-DMT Thread - information from www.bluelight.ru
• Erowid 4-Acetoxy-DMT Vault