Malate dehydrogenase is also involved in gluconeogenesis, the synthesis of glucose from smaller molecules. Pyruvate in the mitochondria is acted upon by pyruvate carboxylase to form oxaloacetate, a citric acid cycle intermediate. In order to get the oxaloacetate out of the mitochondria, malate dehydrogenase reduces it to malate, and it then traverses the inner mitochondrial membrane. Once in the cytosol, the malate is oxidized back to oxaloacetate by cytosolic malate dehydrogenase. Finally, phosphoenol-pyruvate carboxy kinase (PEPCK) converts oxaloacetate to phosphoenol pyruvate.
The Cas number for this type of the enzyme is [9001-64-3].
US Patent Issued to Ramot at Tel-Aviv University on June 11 for "Cytoplasmic Malate Dehydrogenase (MDH1) Targeted Treatment for Neurodegenerative Diseases" (Israeli Inventors)
Jun 11, 2013; ALEXANDRIA, Va., June 11 -- United States Patent no. 8,461,297, issued on June 11, was assigned to Ramot at Tel-Aviv University...