macromolecule, term that may refer either to a crystal such as a diamond, in which the atoms are identical and held by covalent bonds (see chemical bond) of equal strength, or to one of the units that compose a polymer. Macromolecules such as proteins and nucleic acids are vital to the functions of living cells.

Any very large molecule, composed of much larger numbers (hundreds or thousands) of atoms than ordinary molecules. Some macromolecules are individual entities that cannot be subdivided without losing their identity (e.g., certain proteins, with molecular weights into the millions). Others (polymers) are multiples of a repeating building block (monomer) in chains or networks (e.g., plastics, cellulose). Most macromolecules are in the size range typical of colloids.

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