The album was presented as a reunion album because it featured collaborations with former Parliament-Funkadelic members including Bernie Worrell, Bootsy Collins, Junie Morrison, Maceo Parker, and Fred Wesley — some of whom hadn't worked with Clinton in many years. The album also included contributions by current members of the P-Funk All-Stars.
Following the release of T.A.P.O.A.F.O.M., Clinton launched the "Mothership Reconnection Tour" with Bootsy Collins, Bernie Worrell, and the P-Funk All-Stars. The Mothership Reconnection Tour, which began in New York's Central Park, included the landing of a full-scale Mothership on stage, from which Clinton emerged.
The artwork for T.A.P.O.A.F.O.M. was unique among P-Funk albums in that it included contributions by all three artists associated with the band: Pedro Bell, "Stozo the Clown" Edwards, and Overton Loyd.
The Japanese version of "T.A.P.O.A.F.O.M." contains an extra track entitled "Secret Love", co-written by Clinton's son Tracey Lewis aka Trey Lewd.