Lysine 2-monooxygenase

L-lysine + O₂ $rightleftharpoons$ 5-aminopentanamide + CO₂ + H₂O

Thus, the two substrates of this enzyme are L-lysine and O₂, whereas its 3 products are 5-aminopentanamide, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is L-lysine:oxygen 2-oxidoreductase (decarboxylating). Other names in common use include lysine oxygenase, lysine monooxygenase, and L-lysine-2-monooxygenase. This enzyme participates in lysine degradation. It employs one cofactor, FAD.

References

• Nakazawa T, Hori K, Hayaishi O "Studies on monooxygenases. V. Manifestation of amino acid oxidase activity by L-lysine monooxygenase". J. Biol. Chem. 247 3439–44.
• Takeda H, Hayaishi O "Crystalline L-lysine oxygenase". J. Biol. Chem. 241 2733–6.
• Takeda H, Yamamoto S, Kojima Y, Hayaishi O "Studies on monooxygenases. I. General properties of crystalline L-lysine monooxygenase". J. Biol. Chem. 244 2935–41.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes