Lyase

Lyase

[lahy-eys, -eyz]
In biochemistry, a lyase is an enzyme that catalyzes the breaking of various chemical bonds by means other than hydrolysis and oxidation, often forming a new double bond or a new ring structure. For example, an enzyme that catalyzed this reaction would be a lyase:

ATPcAMP + PPi

Lyases differ from other enzymes in that they only require one substrate for the reaction in one direction, but two substrates for the reverse reaction.

Nomenclature

Systematic names are formed as "substrate group lysase." Common names include decarboxylase, dehydratase, aldolase, etc. When the reverse reaction is more important, synthase may be used in the name.

Classification

Lysases are classified as EC 4 in the EC number classification of enzymes. Lyases can be further classified into seven subclasses:

See also

References

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