Louisville, city (1990 pop. 269,063), seat of Jefferson co., NW Ky., at the Falls of the Ohio; inc. 1780. It is the largest city in Kentucky, a port of entry, and an important industrial, financial, marketing, and shipping center for the South and the Midwest. Whiskey distilling is a traditional industry in the city, which also produces the famous Louisville Slugger baseball bats. Other manufactures include motor vehicles; naval ordnance; wood, paper, and tobacco products; processed foods; and computers and software. There is also chemical and aluminum processing and printing and publishing.

A settlement grew after George Rogers Clark built (1778) a fort as a base of operations against the British and the Native Americans. The city was chartered by the Virginia legislature in 1780, when Kentucky was part of Virginia, and named for Louis XVI of France. Louisville developed as a portage place around the falls (until a canal was built in 1830) and as a river port and major commercial center. Many famous steamboats were constructed there. With the arrival of the railroads in the mid-19th cent., the city became the terminus of both the southern and midwestern rail lines, and shipping expanded significantly. During the Civil War it was a center of pro-Union activity in the state and a military and supply base for federal forces.

The Univ. of Louisville (est. 1798), Bellarmine College, Spalding Univ., and two theological seminaries are there, as is Churchill Downs, a noted racetrack and scene of the annual Kentucky Derby (first held in 1875). The city has many parks and is the site of the state fairgrounds. It has a symphony orchestra and an opera company and hosts an annual festival of new American plays. Among the points of interest are the American Printing House for the Blind; the J. B. Speed Art Museum; the Kentucky Center for the Arts; the Muhammad Ali Center, a museum and cultural-educational center honoring the boxing champion and native; the Actors Theatre of Louisville; "Farmington," a historic home (built 1810); the Filson Club, with a historical library and museum; the Jefferson County Courthouse (1850); and Cave Hill Cemetery, where Clark is buried. Nearby are "Locust Grove," the last home (1809-18) of Clark, and the Zachary Taylor National Cemetery, the burial place of Zachary Taylor. Fort Knox is in the area.

Louisville, University of, at Louisville, Ky.; coeducational; founded 1798 as a seminary, became a college and merged in 1837 with the Medical Institute of the City of Louisville (chartered 1833). In 1846 it was reorganized and chartered as the Univ. of Louisville. There are graduate schools of business, engineering, law, and medicine.

City (pop., 2000: 256,231), north-central Kentucky, U.S., located on the Ohio River. Settled in 1778 on Corn Island, it expanded the next year when the settlers moved ashore. Named for Louis XVI of France, it became an important river trading centre and was chartered as a city in 1828. During the American Civil War it served as a Union military headquarters and supply depot. The largest city in Kentucky, it is a leading producer of bonded bourbon whiskey and cigarettes. It is home to the University of Louisville (founded 1798) and Churchill Downs, the site of the Kentucky Derby.

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See Louisville, Kentucky