Loco can refer to the following:

• Loco (loa), a Rada nation patron of healers and plants
• Loco (song), the first single by the band Coal Chamber
• An abbreviation for locomotive
• The Chilean and Peruvian name for the local Abalone
• Loco (computer game), a 1984 computer game for Commodore 64.
• Loco (Audio Programming Language), is an audio programming language designed to be for sound what Logo is for graphics
• Loco (album), a 2001 song and album by the Fun Lovin' Criminals
• Loco Linux, a Linux distribution
• Loco (Apache), an Apache chief
• Loco, Oklahoma is a place in Stephens County
• Loco, Switzerland
• Loco team, a group of Linux and open source advocates
• Loco (Gobots), a character from the Gobots toyline
• Loco (MÄR) - A fictional character in the manga and anime series MÄR
• LocoRoco - Game for PSP(Playstation Portable)and Playstation 3
• Spanish name for the edible mollusc Concholepas concholepas
• Spanish for "crazy".
• The nickname of Manuel Antonio Cange, a footballer
• The nickname of Abdalá Bucaram, former president of Ecuador.
• Loco weed, an American term for some intoxicating plants, also slang for marijuana.