In July 2007, Lisle was ranked #20 in Money magazine's list of "100 Best Places to Live."
A number of firsts for Lisle came in the 1830s with the First Congregational Church of DuPage in 1833, the first post office (managed by John Thompson) in 1834, and the first schoolhouse in 1837.
The railroad came to Lisle in 1864 with the Chicago, Burlington and Quincy Railroad. A fire destroyed the railroad depot, but it was rebuilt in 1874 by the Railroad.
On the 4th of July 2006, Lisle celebrated its 50th birthday by hosting the state's biggest fireworks display.
There were 8,663 households out of which 31.3% had children under the age of 18 living with them, 50.8% were married couples living together, 6.9% had a female householder with no husband present, and 39.5% were non-families. 31.7% of all households were made up of individuals and 6.1% had someone living alone who was 65 years of age or older. The average household size was 2.42 and the average family size was 3.15.
In the village the population was spread out with 24.4% under the age of 18, 8.9% from 18 to 24, 35.5% from 25 to 44, 23.4% from 45 to 64, and 7.9% who were 65 years of age or older. The median age was 35 years. For every 100 females there were 100.7 males. For every 100 females age 18 and over, there were 98.7 males.
The median income for a household in the village was $65,821, and the median income for a family was $86,917. Males had a median income of $56,151 versus $37,104 for females. The per capita income for the village was $35,693. About 1.7% of families and 3.6% of the population were below the poverty line, including 3.2% of those under age 18 and 8.4% of those age 65 or over.
According to the United States Census Bureau, the village has a total area of 6.4 square miles (16.6 km²), of which 6.4 square miles (16.5 km²) is land and 0.1 square miles (0.1 km²) (0.78%) is water.