The following hormones induce lipolysis: epinephrine, norepinephrine, glucagon and adrenocorticotropic hormone. These trigger 7TM receptors, which activate adenylate cyclase. This results in increased production of cAMP, which activates protein kinase A, which subsequently activate lipases found in adipose tissue.
Triglycerides undergo lipolysis (hydrolysis by lipases) and are broken down into glycerol and fatty acids. Once released into the blood, the relatively hydrophobic free fatty acids bind to serum albumin for transport to tissues that require energy. The glycerol also enters the bloodstream and is absorbed by the liver or kidney where it is converted to glycerol 3-phosphate by the enzyme glycerol kinase. Hepatic glycerol 3-phosphate is mostly converted into dihydroxyacetonephosphate (DHAP) and then glyceraldehyde 3-phosphate (G3P) to rejoin the glycolysis and gluconeogenesis pathway.
Adiponectin Inhibits Spontaneous and Catecholamine-Induced Lipolysis in Human Adipocytes of Non-Obese Subjects Through AMPK-Dependent Mechanisms
Jan 01, 2011; Summary Adiponectin is an adipokine increasing glucose and fatty acid metabolism and improving insulin sensitivity. The aim of...