Cinnamoyl-CoA reductase

cinnamaldehyde + CoA + NADP⁺ $rightleftharpoons$ cinnamoyl-CoA + NADPH + H⁺

The 3 substrates of this enzyme are cinnamaldehyde, CoA, and NADP⁺, whereas its 3 products are cinnamoyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating). Other names in common use include feruloyl-CoA reductase, cinnamoyl-coenzyme A reductase, ferulyl-CoA reductase, feruloyl coenzyme A reductase, p-hydroxycinnamoyl coenzyme A reductase, and cinnamoyl-CoA:NADPH reductase. This enzyme participates in phenylpropanoid biosynthesis.

References

• Gross GG, Kreiten W "Reduction of coenzyme A thioesters of cinnamic acids with an enzyme preparation from lignifying tissue of Forsythia". FEBS. Lett. 54 259–62.
• Sarni F, Grand C, Boudet AM "Purification and properties of cinnamoyl-CoA reductase and cinnamyl alcohol dehydrogenase from poplar stems (Populus X euramericana)". Eur. J. Biochem. 139 259–65.
• Wengenmayer H, Ebel J, Grisebach H "Enzymic synthesis of lignin precursors. Purification and properties of a cinnamoyl-CoA: NADPH reductase from cell suspension cultures of soybean (Glycinemax)". Eur. J. Biochem. 65 529–36.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes