Arrowsmith (1925; Pulitzer Prize, refused by Lewis) satirizes the medical profession, and Elmer Gantry (1927) attacks hypocritical religious revivalism. Dodsworth (1929), a more mellow work, is a sympathetic picture of a wealthy American businessman in Europe; it was successfully dramatized by Lewis and Sidney Howard in 1934. In 1930, Lewis became the first American to win the Nobel Prize in Literature. During his lifetime he published 22 novels, and it is generally agreed that his later novels are far less successful than his early fiction. Among his later works are It Can't Happen Here (1935), Cass Timberlane (1945), Kingsblood Royal (1947), and World So Wide (1951). From 1928 to 1942 Lewis was married to Dorothy Thompson, 1894-1961, a distinguished newspaperwoman and foreign correspondent.
See memoir by his first wife, G. H. Lewis (1955); biographies by C. Van Doren (1933, repr. 1969), M. Shorer (1961), V. Sheean (1963), and R. Lingeman (2001); studies by S. N. Grebstein (1962, repr. 1987), D. J. Dooley (1967, repr. 1987), M. Light (1975), and M. Bucco, ed. (1986).