Scyllo-inosamine-4-phosphate amidinotransferase

In enzymology, a scyllo-inosamine-4-phosphate amidinotransferase is an enzyme that catalyzes the chemical reaction

L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate rightleftharpoons L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate

Thus, the two substrates of this enzyme are L-arginine and 1-amino-1-deoxy-scyllo-inositol 4-phosphate, whereas its two products are L-ornithine and 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the amidinotransferases. The systematic name of this enzyme class is L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase. Other names in common use include L-arginine:inosamine-P-amidinotransferase, inosamine-P amidinotransferase, L-arginine:inosamine phosphate amidinotransferase, and inosamine-phosphate amidinotransferase. This enzyme participates in streptomycin biosynthesis.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .


  • Walker MS and Walker JB "Enzymic studies on the biosynthesis of streptomycin, transamidation of inosamine and streptamine derivatives". J. Biol. Chem. 241 1262–1269.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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