Alkane 1-monooxygenase

octane + reduced rubredoxin + O₂ $rightleftharpoons$ 1-octanol + oxidized rubredoxin + H₂O

The 3 substrates of this enzyme are octane, reduced rubredoxin, and O₂, whereas its 3 products are 1-octanol, oxidized rubredoxin, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced iron-sulfur protein as one donor, and incorporation o one atom of oxygen into the other donor. The systematic name of this enzyme class is alkane,reduced-rubredoxin:oxygen 1-oxidoreductase. Other names in common use include alkane 1-hydroxylase, omega-hydroxylase, fatty acid omega-hydroxylase, alkane monooxygenase, 1-hydroxylase, and alkane hydroxylase. This enzyme participates in 3 metabolic pathways: fatty acid metabolism, arachidonic acid metabolism, and ppar signaling pathway. It employs one cofactor, heme.

References

• Cardini G, Jurtshuk P "The enzymatic hydroxylation of n-octane by Corynebacterium sp strain 7E1C". J. Biol. Chem. 245 2789–96.
• McKenna EJ, Coon MJ "Enzymatic omega-oxidation. IV. Purification and properties of the omega-hydroxylase of Pseudomonas oleovorans". J. Biol. Chem. 245 3882–9.
• Peterson JA, Kusunose M, Kusunose E, Coon MJ "Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation". J. Biol. Chem. 242 4334–40.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes