Its protagonists are Hamm, an aged master who is blind and not able to stand up, and his servant Clov, who cannot sit down. They exist in a tiny house by the sea, although the dialogue suggests that there is nothing left outside—no sea, no sun, no clouds. The two characters, mutually dependent, have been fighting for years and continue to do so as the play progresses. Clov always wants to leave but never seems to be able. Also present are Hamm's legless parents Nagg and Nell, who live in rubbish bins upstage and initially request food or argue inanely.
The literary critic Harold Bloom considers Hamm to be an allusion to Hamlet and finds an intertext (transumptive litotes) within Hamm's line:
It has also been suggested that Hamm also relates to ham actor and Ham, son of Noah, while Clov is a truncated version of Clown, as well as suggesting cloven hoof (of the devil) and glove (a distant echo of hand and glove, perhaps). Nagg suggests nagging and the German nagen (to gnaw), while Nell recalls Dickens' Little Nell. (Theodor Adorno Trying to Understand Endgame). Equally Hamm could be short for Hammer and Clov be clove (etymologically nail
), hammer and nail representing one aspect of their relationship. In this light, Nagg and Nell, taken together, may suggest the German Nagel (nail).
Ruby Cohn, in her book Back to Beckett, writes that "Beckett's favorite line in the play is Hamm's deduction from Clov's observation that Nagg is crying: 'Then he's living.' But in Berlin he felt that the most important sentence is Nell's 'Nothing is funnier than unhappiness.' And he directed his play to show the fun of unhappiness."
The implication in the play is that the characters live in an unchanging, static state. Each day contains the actions and reactions of the day before, until each event takes on an almost ritualistic quality. It is made clear, through the text, that the characters have a past (most notably through Nagg and Nell who conjure up memories of tandem rides in the Ardennes). However, there is no indication that they may have a future. Even the death of Nell, which occurs towards the end of the play, is greeted with a lack of surprise. The isolated setting, and the constant references to aspects of civilisation that no longer exist, have led many to suggest the play is post-nuclear. However, Beckett always denied this.