The is the youngest of the four shinnōke, branches of the Imperial Family of Japan which were eligible to succeed to the Chrysanthemum Throne in the event that the main line should die out. It was founded by Prince Naohito, the son of Emperor Higashiyama.
Fearing extinction of the Imperial Line, Arai Hakuseki proposed that a new branch of the Imperial Family be created. In 1718, retired emperor Reigen bestowed upon his grandson the title of Kan'in-no-miya and land worth 1000 koku. This was the first new miyake was formed since the Arisugawa-no-miya lineage in 1625.
Arai Hakusei's wisdom was soon proved with the second Kan'in-no-miya, Sukehito shinnō. When Emperor Go-Momozono died, he had only a single daughter. Sukehito's son was chosen to become Emperor Kōkaku.
The Kan'in House went extinct upon the death of its 5th head, Prince Naruhito, in 1842, but was revived by Emperor Meiji, who assigned the name to Prince Kotohito, 16th son of Prince Fushimi Kunie (one of the other shinnoke houses).
The line went extinct again with the death of his son, Kan'in Sumihito (formerly Kan'in-no-miya Haruhito shinnō) in 1988.