Toxication may involve:
While toxication is generally undesirable, in certain cases it is required for the in vivo conversion of a prodrug or chemical to a metabolite with desired pharmacological or toxicological activity. Codeine is an example of a prodrug, which is metabolized in the body to the opioid known as morphine.
The breakdown of methanol in the mammalian liver. Methanol in itself is toxic due to its CNS depressant properties, but acquires more dangerous toxicity through its metabolites formic acid and formaldehyde, which can cause severe acidosis, damage to the optic nerve, and other life-threatening complications.
Metabolic Activation of N-Hydroxy-2-aminofluorene and N-Hydroxy-2-acetylaminofluorene by Monomorphic N-Acetyltransferase (NAT1) and Polymorphic N-Acetyltransferase (NAT2)
Role of cytochrome P4501B1 in benzo[a]pyrene bio-activation to DNA-binding metabolites Evidence from 32p-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates