Immunophilins

Immunophilins
In molecular biology, immunophilins are peptidyl-prolyl isomerases that intraconvert between the cis and trans positions.

Immunophilins are targeted by immunosuppressive drugs such as rapamycin, cyclosporin, and FK-506. For these drugs in particular, known immunophilins such as cyclophilin catalyze the cis-trans isomerization of peptide bonds, particularly X-Pro peptide bonds. However, this isomerase activity appears to be unrelated to their ability to bind these drugs.

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Last updated on Wednesday May 21, 2008 at 10:10:03 PDT (GMT -0700)
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