While nearly all of the variables listed above are at least partially determined or affected by genetic factors, few of them are controlled by simple Mendelian inheritance. Most are polygenic or are determined by a complex combination of genes and early environment. Essentially, genes provide proclivities and potentialities continuously involving feedback mechanisms with the environment throughout life, but especially during prenatal and early childhood.
Many genetic differences (polymorphisms) have little effect on health or reproductive success, but serve to statistically distinguish one population from another. Researchers in the field of population genetics have been using these to elucidate ancient migrations and relationships between population groups.
Another purely genetic set of individual differences are the blood types and immune types we all carry. While some may carry mild advantages or disadvantages in terms of risks of particular diseases, the primary life-or-death significance comes when we attempt to transfer blood or organs from one person to another. Our immune system is designed to recognize these human differences with great sensitivity and enforce our individuality.
Possession of above average amounts of some abilities is valued by most societies: ability to learn; musical aptitude; strength, endurance, agility; resilience.
Each individual's distinctive differences, even the negatively valued ones, are usually considered an essential part of self-identity. Membership or status in a social group may depend on having specific values for certain attributes. It is not unusual for people to deliberately try to amplify or exaggerate differences, or to conceal or minimize them, for a variety of reasons. Examples of practices designed to minimize differences include hair straightening or skin bleaching, plastic surgery, orthodontia, and growth hormone treatment for extreme shortness. Conversely, male-female differences are enhanced and exaggerated in most societies.
These differences may vary or be distributed in various ways. Some, like height for a given sex, vary in close to a "normal" or Gaussian distribution. Some characteristics (e.g., skin color) vary continuously in a population, but the continuum may be socially divided into a small number of distinct categories. Some characteristics vary bimodally (for example, handedness), with fewer people in intermediate categories.
Different human societies may assign different values to various differences. The obvious examples are race and sex, while handedness has a much weaker value difference, but nearly all human differences will have social value dimension. In some societies, such as the United States, circumcision is practiced on a majority of males, as well as sex reassignment of intersex infants, with substantial emphasis on cultural norms.
Much social controversy surrounds the assigning or distinguishing of some categories, with variation between groups in a society or between societies as to the degree to which a difference is part of a person's "essential" nature or is partly a socially constructed attribution. For example, in the United States and Europe there has been a centuries-long debate over whether sexual orientation is an essential part of one's nature (the "essentialist" position), or a result of mutually reinforcing social perceptions and behavioral choices (the "constructivist" perspective). Other cultures may not even understand the controversy.
Controversy also surrounds the boundaries of "wellness", "wholeness," or "normality." In some cultures, physical imperfections can exclude one from religious service. In western culture there has been large-scale renegotiation of the social significance of variations which reduce the ability of a person to do one or more functions. Laws have been passed to alleviate the reduction of social opportunity available to those with disabilities. The concept of "differently abled" has been pushed by those persuading society to see limited incapacities as a human difference of less negative value.
When an inherited difference of body structure or function is severe enough, it is termed a genetic disease, but even this classification has fuzzy edges. There are many instances in which the degree of negative value of a human difference depends completely on the social or physical environment. For example, in a society with a large proportion of deaf people (as Martha's Vineyard in the 19th century), it was possible to deny that deafness is a disability. Another example of social renegotiation of the value assigned to a difference is reflected in the controversy over management of ambiguous genitalia, especially whether abnormal genital structure has enough negative consequences to warrant surgical correction.
Furthermore, many genetic traits may be advantageous in certain circumstances and disadvantageous in others. Being a heterozygote or carrier of the sickle-cell disease gene confers some protection against malaria, apparently enough to maintain the gene in populations of malarial areas. In a homozygous dose it is a significant disability.
The extreme exercise of social valuation of human difference is in the definition of "human." What difference is great enough to assign an individual "nonhuman" status, in the sense of withholding our identification, charity, and social participation? This can change enormously between cultures and over time. For example, nineteenth century European and American ideas of race and eugenics culminated in the attempts of the Nazi-led German society of the 1930s to deny not just reproduction, but life itself to a variety of people with "differences" attributed in part to biologic characteristics. Western society's revulsion to this contributed to a considerable readjustment of valuation of differences.
Contemporary controversy continues over "what kind of human" is a fetus or child with a significant disability. On one end are people who would argue that Down's syndrome is not a disability but a mere "difference," and on the other those who consider such a calamity as to assume that such a child is better off "not born". In India and China, being female is widely considered such a negatively valued human difference that similar decisions are made by the hundreds of thousands.
Acknowledgement and study of human differences does have a wide range of uses, such as tailoring the size and shape of manufactured items. See Ergonomics.