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hydroxylase
Cholesterol 7 alpha-hydroxylase
Cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the synthesis of bile acid from cholesterol, catalyzing the formation of 7-alpha-hydroxycholesterol.
It is downregulated by Sterol regulatory element binding proteins (SREBP) when plasma cholesterol levels are low. It is upregulated by the nuclear receptor LXR (liver X receptor) when cholesterol (specifically - oxysterol) levels are high. The effect of this upregulation is to increase the production of bile acids and reduce the level of cholesterol in hepatocytes.
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This article is licensed under the GNU Free Documentation License.
Last updated on Friday June 06, 2008 at 15:47:17 PDT (GMT -0700)
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This article is licensed under the GNU Free Documentation License.
Last updated on Friday June 06, 2008 at 15:47:17 PDT (GMT -0700)
View this article at Wikipedia.org - Edit this article at Wikipedia.org - Donate to the Wikimedia Foundation
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