Hunter-Killer is a military term traditionally used to describe an entity in which the roles of "sensor" and "shooter" are separated. However, in the case of unmanned aerial vehicles, it means the opposite: an aircraft system designed to find, identify and kill its target; the first purpose-designed hunter-killer UAV is the MQ-9 Reaper.
A hunter-killer team's primary mission is to seek out and destroy the enemy, particularly in contexts where the enemy is attempting to evade detection rather than seek engagement.
Smaller submarines tasked with coastal defense are sometimes referred to as "hunter-killers" even though they may not operate in teams with other platforms. The United States Navy and the Royal Navy give their Nuclear powered hunter-killer submarines the hull classification symbol "SSN". Conventionally powered hunter-killer submarines, such as those operated by the Canadian Navy are given the hull classification symbol "SSK".
A hunter-killer sight in an armoured vehicle refers to a vehicle commander's sight which is independent of the gunner's sight and main armament. It allows the crew commander to scan an arc separate from the gunner, or for the crew commander to continue scanning while the gunner engages a target. With the press of a button, the crew commander can cause the gunner's sight and the main armament to slew onto his point of aim.
In the Terminator saga, Hunter Killers are a series of various types of unmanned vehicles built in automated factories.
In the game Command and Conquer: Tiberian Sun, a hunter-seeker is an unmanned, uncontrollable drone that will hunt down and destroy a random enemy unit or building
In a novel series by American novelist, Brett Kihlmire, Hunter-Killers are an elite faction of asassins serving as the private army of the Emperor of the fictitious Russian Empire
There are also two songs named "Hunter/Killer" and "Hunter/Killer: Endgame" from the album Day Into Night, by the Canadian band Quo Vadis.