From the show's debut until September 2006, Brian Kenny hosted the show. In October 2006, he became an anchor on SportsCenter, and was replaced on THL by Elliott and Bunin, who had been substitutes for Kenny in the past. However, beginning in August 2007, David Lloyd, who had been the host on ESPNEWS Pregame, took over as the permanent host. Michael Kim had been the primary update anchor since 2004, but Ben Becker has also served in that role. In the spring of 2008, the show's current dual-anchor format was adopted.
In 2006, two special edition five hour shows debuted. On Mondays during the NFL season, an extended five hour show began at 1pm ET to kick off ESPN's coverage of Monday Night Football with Josh Elliott and Mike Hill co-hosting and Eric Allen and Qadry Ismail as analysts. This replaced Monday Quarterback which was hosted by Trey Wingo with Mike Ditka and Eric Allen. On Thursdays, the show aired a special college football preview show, again five hours with Dari Nowkhah hosting along with analysts Jim Donnan and Lou Holtz.