Homogentisic acid

[hoh-muh-jen-tis-ik, -tiz-, hoh-]
Homogentisic acid is the common name for 2,5-dihydroxyphenylacetic acid.

It is less commonly known as "Melanic acid", the name chosen by William Prout.


Accumulation of excess homogentisic acid is a result of the failure of the enzyme homogentisic acid 1,2-dioxygenase (typically due to a mutation) and is associated with alkaptonuria.

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