Homatropine

Homatropine

Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic, to temporarily paralyze accommodation, and as a mydriatic, to dilate the pupil.

Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide or methylbromide salt.

Certain preparations of drugs such as hydrocodone are mixed with a small, sub-theraputic amount homatropine methylbromide to discourage intentional overdose.

Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.

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References

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