(Equipin, Isopto Homatropine) is an anticholinergic medication
that inhibits muscarinic acetylcholine receptors
and thus the parasympathetic nervous system
. It is used in eye drops
as a cycloplegic
, to temporarily paralyze accommodation
, and as a mydriatic
, to dilate the pupil
Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide or methylbromide salt.
Certain preparations of drugs such as hydrocodone are mixed with a small, sub-theraputic amount homatropine methylbromide to discourage intentional overdose.
Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.