He is co-founder of Carib Gems and Pressure Sounds, and founder of Hitrun Records as well as Green Tea Records and Soundboy Records. His most well-known label is On-U Sound Records. He is also the fourth member of industrial hip-hop outfit Tackhead, credited as "mixologist."
In 1986 he began working Jamaican dub producer and singer Lee Perry. They produced the classic album "Time Boom X De Devil Dead" and Sherwood's support helped relaunch Perry's career.
He made contributions to the industrial genre in his remix of Einstürzende Neubauten's song Yü Gung, on the album Halber Mensch, as well as his production work with Ministry, Cabaret Voltaire, KMFDM, Terminal Power Company and Nine Inch Nails. Adrian has also contributed to the blues, with his Little Axe project with Skip McDonald, producing his album on Real World Records Champagne and Grits in 2006.
In 2003, Adrian Sherwood released his first album as a solo artist, Never Trust a Hippie? which featured collaborations with various artists such as Sly & Robbie, Steven "Lenky" Marsden, Carlton "Bubblers" Ogilvie and Jazzwad.
In 2006 he released his second album Becoming A Cliché that again featuring numerous artists such as Lee "Scratch" Perry, the late Bim Sherman, Dennis Bovell, Little Roy, Lee 'LSK' Kenny, Samia Farah, Raiz and Mark Stewart. A limited 2-disc version was released simultaneously with the second disc titled "Dub Cliché".
On beginning a solo career, Sherwood stated, "I wanted to do some of my own writing and make something that was challenging for me...As a producer, it’s my job to satisfy the artist foremost. I wanted to make something that was a little more aggressive and modern. I wanted to paint a picture that was contemporary, one that specifically showed where my brain was at. I’ve got to the point in my life where it’s time for me to call all of the shots.