His or HIS may refer to:

• a gender-specific pronoun, the possessive form of he
• His, Haute-Garonne, a commune in the Haute-Garonne département, in France
• Hospital information system, an enterprise resource planning system that caters to hospital needs
• Honeywell Information Systems, the former computer division of Honeywell
• Histidine, an amino acid
• Wilhelm His, Sr., a cell theorist
• Wilhelm His, Jr., an anatomist
• Microsoft Host Integration Server, a technology to connect a Microsoft Windows platform with a non-Microsoft platform such as IBM mainframes.

See also

• hiss