Hippoboscidae, the louse flies or keds are obligate parasites of mammals and birds. In this family there are winged species which can fly at least reasonably well, as well as others with vestigial or no wings which are flightless and highly apomorphic. As usual in their superfamily Hippoboscoidea, most of the larval development takes place within the mother's body, and pupation occurs almost immediately.
The sheep ked, Melophagus ovinus, is a wingless, reddish-brown fly that parasitizes sheep. The Neotropical deer ked, Lipoptena mazamae, is a common ectoparasite of white-tailed deer (Odocoileus virginianus) in the southeastern United States. Both winged and wingless forms may be seen. A common winged species is Hippobosca equina, called "the louse fly" among riders. Species in other genera are found on birds, for example, Ornithomya bequaerti has been collected from birds in Alaska. Hippoboscidae are also common parasites of the Tawny Frogmouth (Podargus strigoides) of Australia.
Pseudolynchia canariensis is commonly found on pigeons and doves, and can serve as the vector of pigeon malaria. There is some evidence that other Hippoboscidae can serve as vectors of disease agents to mammals.