The work carries a simple form, with a dramatic multitextural section leading into a calm resolution (if such a thing exists in Berio's music) at the end. The guitar Sequenza is also one of the longest Sequenzas, the longest being Sequenza XII, the bassoon Sequenza. A variety of guitar techniques are explored in this piece including rasqueado (from the flamenco tradition), tremolo, glissando, harmonics, tambour (percussive effects). In terms of harmony, the work is based on the guitar's characteristic harmony/tuning, i.e., the interval of a perfect fourth. Set class 6-7 also underlies most of the linear material.
Sequenza XI is a standard work for guitarists who have chosen avant-garde modern classical music as a part of their repertoire, e.g., Denis Sung-Hô (Sequenza's performance with members of the Ensemble InterContemporain), Stefan Östersjö, Todd Seelye, Mats Scheidegger, Geoffrey Morris, Pablo Gómez, Pablo Márquez, Alan Thomas, Jürgen Ruck, etc.: it has been recorded numerous times (see below).
Chemins V by Berio is a work by Berio based on Sequenza XI, for guitar and ensemble.