These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain that interacts either with other CAMs of the same kind (homophilic binding) or with other CAMs or the extracellular matrix (heterophilic binding).
Immunoglobulin superfamily CAMs (IgSF CAMs) are either homophilic or heterophilic and bind integrins or different IgSF CAMs.
Here is a list of some molecules of this family:
The integrins are a family of heterophilic CAMs that bind IgSF CAMs or the extracellular matrix. They are heterodimers, consisting in two noncovalently-linked subunits, called alpha and beta. Twenty-four different alpha subunits that can link in many different combinations with the 9 different beta subunits are known; however not all combinations are observed.
Some sources (for example, MeSH) don't consider integrins to be cell adhesion molecules.
The selectins are a family of heterophilic CAMs that bind fucosylated carbohydrates, e.g., mucins. They are calcium-dependent. The three family members are E-selectin (endothelial), L-selectin (leukocyte), and P-selectin (platelet). The best-characterized ligand for the three selectins is P-selectin glycoprotein ligand-1 (PSGL-1), which is a mucin-type glycoprotein expressed on all white blood cells.
Neutrophils and eosinophils bind to E-selectin. One of the reported ligands for E-selectin is the sialylated Lewis X Ag (sLe(x)). Eosinophils, like neutrophils, use sialylated, protease-resistant structures to bind to E-selectin, although the eosinophil expresses much lower levels of these structures on its surface. Ligands for P-selectin on eosinophils and neutrophils are similar sialylated, protease-sensitive, endo-beta-galactosidase-resistant structures, different than those reported for E-selectin, suggesting disparate roles for P-selectin and E-selectin during recruitment during inflammatory responses.
Mental retardation and other neurological disorders are attributable in part to disruption of normal cell adhesion
Use of an In Vivo Biotinylated Single-Chain Antibody as Capture Reagent in an Immunometric Assay to Decrease the Incidence of Interference from Heterophilic Antibodies
May 01, 2005; Background: heterophilic antibodies are a common source of interference in immunometric assays. We tested the hypothesis...
Detection and Elimination of Interference by the Heterophilic Antibody in Antibody Microarray-Based Immunoassay
Mar 01, 2011; To the Editor: Antibody microarray- based multiplex immunoassays can be applied in the early and differential diagnosis, staging,...