hematuria

Blood in the urine. It usually indicates injury or disease of the kidney or another structure of the urinary system or possibly, in males, the reproductive system. It may result from infection, inflammation, tumours, kidney stones, or other disorders. How the blood looks and when it appears in the urine stream reflect whether it originates in the urethra, the bladder, or the kidney.

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In medicine, hematuria (or "haematuria") is the presence of red blood cells (erythrocytes) in the urine. It can be a sign that there is a kidney stone or a tumor in the ureter, urinary bladder, prostate, or urethra. kidneys and the urinary tract, ranging from trivial to lethal. If white blood cells are found in addition to red blood cells, then it is a signal of urinary tract infection.

Occasionally "hemoglobinuria" is used synonymously, although more precisely it refers only to hemoglobin in the urine.

Types

Red discolouration of the urine can have various causes:

• Red blood cells
• Microscopic hematuria (small amounts of blood, can be seen only on urinalysis or light microscopy)
• Macroscopic hematuria (or "frank" or "gross") hematuria
• Hemoglobin (only the red pigment, not the red blood cells)
• Other pigments
• Porphyrins in porphyria
• Betanin, after eating beets

Analysis

A patient will be asked a number of questions:

• Have you passed any blood clots?
• Has a kidney stone been passed (noise in toilet bowl)?
• Is the red colour mixed in completely, or does the colour change during an episode of urination?
• Does it occur only after getting up?
• Have you recently had a sore throat?

Diagnosis

Often, the diagnosis is made on the basis of the medical history and some blood tests—especially in young people in whom the risk of malignancy is negligible and the symptoms are generally self-limited.

Ultrasound investigation of the renal tract is often used to distinguish between various sources of bleeding. X-rays can be used to identify kidney stones, although CT scanning is more precise.

In older patients, cystoscopy with biopsy of suspected lesions is often employed to investigate for bladder cancer.

Causes

Common causes of macroscopic hematuria/ haematuria (i.e. blood visible in the urine) include:

• Benign familial hematuria
• Urinary Schistosomiasis (caused by Schistosoma haematobium) - a major cause for hematuria in many African and Middle-Eastern countries;
• IgA nephropathy ("Berger's disease") - occurs during viral infections in predisposed patients;
• Kidney stones (or bladder stones, now a rare disease);
• Bladder cancer;
• Renal cell carcinoma - occasionally presents with bleeding;
• Paroxysmal nocturnal hemoglobinuria - a rare disease where hemoglobin of hemolysed cells is passed into the urine.
• Urinary tract infection with some bacterial species including strains of EPEC and Staphylococcus saprophyticus
• Sickle cell trait can precipitate large amounts of red blood cell discharge, but only a small number of individuals endure this problem
• Arteriovenous malformation of the kidney (rare, but may impress like renal cell carcinoma on scans as both are highly vascular)
• Nephritic syndrome (a condition associated with post-streptococcal and rapidly progressing glomerulonephritis).
• Ureteral Pelvic Junction Obstruction (UPJ) is a rare condition beginning from birth in which the ureter is blocked between the kidney and bladder. This condition may cause blood in the urine.

References