Myosin-heavy-chain kinase

ATP + [myosin heavy-chain] $rightleftharpoons$ ADP + [myosin heavy-chain] phosphate

Thus, the two substrates of this enzyme are ATP and [myosin heavy-chain], whereas its two products are ADP and myosin heavy-chain phosphate.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[myosin heavy-chain] O-phosphotransferase. Other names in common use include ATP:myosin-heavy-chain O-phosphotransferase, calmodulin-dependent myosin heavy chain kinase, MHCK, MIHC kinase, myosin heavy chain kinase, myosin I heavy-chain kinase, myosin II heavy-chain kinase, [myosin-heavy-chain] kinase, myosin heavy chain kinase A, and STK6.

References

• Cote GP, Bukiejko U "Purification and characterization of a myosin heavy chain kinase from Dictyostelium discoideum". J. Biol. Chem. 262 1065–72.
• Hammer JA 3rd Albanesi JP, Korn ED "Purification and characterization of a myosin I heavy chain kinase from Acanthamoeba castellanii". J. Biol. Chem. 258 10168–75.
• Rieker JP, Swanljung-Collins H, Collins JH "Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border". J. Biol. Chem. 262 15262–8.
• Ravid S, Spudich JA "Myosin heavy chain kinase from developed Dictyostelium cells Purification and characterization". J. Biol. Chem. 264 15144–50.
• Brzeska H, Lynch TJ, Martin B, Corigliano-Murphy A, Korn ED "Substrate specificity of Acanthamoeba myosin I heavy chain kinase as determined with synthetic peptides". J. Biol. Chem. 265 16138–44.
• Ravid S, Spudich JA "Membrane-bound Dictyostelium myosin heavy chain kinase: a developmentally regulated substrate-specific member of the protein kinase C family". Proc. Natl. Acad. Sci. U. S. A. 89 5877–81.
• Futey LM, Medley QG, Cote GP, Egelhoff TT "Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins". J. Biol. Chem. 270 523–9.
• Korn ED, Brzeska H "Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase". Proc. Natl. Acad. Sci. U. S. A. 95 4146–51.
• Egelhoff TT, Croft D, Steimle PA "Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly". J. Biol. Chem. 280 2879–87.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes