|Awarded:||9 June 1960|
|Laid down:||28 February 1961|
|Launched:||15 May 1965|
|Commissioned:||20 December 1966|
|Stricken:||4 February 1992|
|Complement:||99 officers and men|
|Armament:||4 × 21 in (533 mm) torpedo tubes|
USS Guardfish (SSN-612), a Thresher-class submarine, was the second ship of the United States Navy to be named for the guardfish, a voracious green and silvery fish with elongated pike-like body and long narrow jaws.
The contract to build her was awarded to New York Shipbuilding Corporation in Camden, New Jersey on 9 June 1960 and her keel was laid down on 28 February 1961. She was launched on 15 May 1965 sponsored by Mrs. Kenneth E. Belieu, wife of the Assistant Secretary of the Navy, and commissioned on 20 December 1966 with Commander Gulmer A. Hines, Jr. in command.
Guardfish was decommissioned and stricken from the Naval Vessel Register on 4 February 1992. Her hulk entered the Nuclear Powered Ship and Submarine Recycling Program and ceased to exist on 9 July 1992.